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Laboratory of Evolutionary Genetics at USP 

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How does selection shape genetic differentiation? Comparing differentiation at selected and neutral loci, we uncover the dynamics of selection. Figure from Débora Brandt's paper

 

For longer divergence times, Fst is lower at HLA than genomewide. However, for recently diverged population pairs, this trend is reversed. We propose a model to address this finding.

Which genes are under balancing selection? We have developed a test to identify targets of selection, and explore their biological importance. Figure from Bárbara Bitarello's paper.

 

 

 

 
 

How does natural selection shape variation at MHC genes? The MHC is unusually polymorphic. But can we identify the selective regime driving this pattern?

 

 

What are the deleterious consequences of natural selection? Deleterious variants can hitchhike along with advantageous ones. We explore this dynamic in the MHC region.

 

 
Can we recent selection in the genomes of admixed populations?Recent selection can cause changes in ancestry proportions. Is this visible in admixed Brazilians? Figure from Kelly Nune's work summarized in our review paper.

 

African ancestry appears to be enriched in the MHC region, with respect to the remainder of the genome. Here we show this result for the Quilombola individuals of Brazil. This may indicate selection favoring alleles of African ancestry within the admixed populations. 

 

Our research includes both bioinformatic analyses of publicly available data, as well as of datasets generated by us.

 

 

Teaching

BIO0312-2015 - Biologia Evolutiva

Prova BIO 0312

Notas BIO0312

Genomica Evolutiva

Prática BIO208: http://www.ib.usp.br/genevol/images/aula6.pdf